Immune System Diseases

Disorders of the immune system may prevent gainful activity because of a serious loss of function of a single organ or body system, or lesser degrees of functional loss in two or more organs or body systems resulting in significant symptoms — severe fatigue, fever, malaise, weight loss, joint pain, and stiffness.

These conditions generally evolve and persist for extended periods and may require long-term, repeated evaluation and management. The Social Security Administration evaluates them under the Listing of Impairments for immune system disorders.

Building a successful claim requires careful documentation of organ involvement, treatment history, and the cumulative functional impact of symptoms across multiple body systems.